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The detrusor muscle is a muscle found in the bladder wall. Sometimes, it can have uncontrollable spasms. This is called an overactive bladder. Overactive detrusor muscles can cause an increased frequency of passing urine or uncontrollable urges to urinate.
Tolterodine relaxes the bladder wall's detrusor muscles. It is achieved by blocking the muscarinic nerves at the surface of muscle cells. This will stop acetylcholine, a natural chemical, from binding to the receptors.
Normally, the acetylcholine acting upon the receptors will cause detrusor muscles to contract and the bladder to empty. Tolterodine blocks acetylcholine and helps the bladder wall muscle relax. It reduces the involuntary, unstable contractions of the bladder, increasing bladder capacity to hold urine. It also reduces the need for urine to be passed.
Detrusitol comes in an immediate-release form, meaning that it is absorbed from the stomach quickly after being taken.
Read the information leaflet thoroughly for the instructions on how to take it.
Take this prolonged-release tablet as a whole with a glass of water. Do not chew or break it. It may be taken before, during, or after a meal.
If you forget to take it on time, take it when you remember. If it is almost time for the next dose, skip the missed dose and take another as scheduled. Do not double up the dosage to make up for the missed one.
Consult your doctor before you want to stop taking Detrusitol.
Follow your doctor's instructions. If you have any questions about how to take Detrusitol, consult your doctor.
Consult your doctor immediately if you have the following symptoms:
Swollen face, tongue, or pharynx
Difficulty in swallowing
Hives and difficulty in breathing
Difficulty breathing at night
Swelling of legs
Sensations of pins and needles
Inability to empty bladder
Other reactions include confusion, hallucinations and increased heart rate. According to some reports, dementia patients treated with Detrusitol can experience worsening symptoms.
You should immediately inform your doctor if you experience any side effects related to Detrusitol.
Detrusitol can make you restless, dizzy or affect your vision, which may impair your ability to drive and operate machinery.
Detrusitol has sucrose, so tell your doctor if you are allergic to certain sugars. Detrusitol is not for individuals with glucose-galactose malabsorption or fructose intolerance.
Disclose to your doctor before you start the treatment if:
you are pregnant or planning to get pregnant;
you are breastfeeding;
you are taking any other prescription or non-prescription medicine; or
you are allergic to any ingredients of the Detrusitol.
Some medications are not compatible with Detrusitol, such as antifungals, macrolide antibiotics and HIV protease inhibitors.
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